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METROGEL-VAGINAL is definitely the intravaginal dosage form of the artificial antibacterial agent, metronidazole, USP at a focus of 0.75%. Metronidazole is really a member on the imidazole course of antibacterial agents and is classed therapeutically being an antiprotozoal and anti‑bacterial agent.

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Metronidazole has demonstrated proof of carcinogenic action in numerous reports involving Continual oral administration in mice and rats. Outstanding amid the results while in the mouse was the promotion of pulmonary tumorigenesis. This has actually been observed in all 6 reported reports in that species, which includes a single study through which the animals were being dosed on an intermittent routine (administration during every single fourth week only). At pretty higher dose levels (close to 500 mg/kg/working day), there was a statistically considerable boost in the incidence of malignant liver tumors in males.

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Patients with intense hepatic illness metabolize metronidazole gradually. This ends in the accumulation of metronidazole and its metabolites within the plasma. Accordingly, for this kind of people, metronidazole vaginal gel should be administered cautiously.

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